Exponential Wisdom

Episode 105: Living Past 100 Years

by

Peter and Dan discuss the wide-ranging implications of today’s biotech and longevity breakthroughs, now adding years to the human healthspan.

In this episode:

  • Peter mentions the significance of Dr. David Sinclair’s latest cover-featured publication in Nature, which offers groundbreaking evidence for reversal of age-related decline in mice– an advancement now being tested and validated in in vitro human cells.
  • Dan talks about the importance of nurturing friendships with those younger than you, a key step in nurturing a youthful mindset. Peter further shows how such relationships can contribute to a healthier mentality about taking risks.
  • Peter discusses the implications of adding 30 healthy years to one’s life. For one: by the time you are 60 years old, you have accumulated the majority of your wealth, whether in terms of capital, relationships, or intelligence. By extending our healthy years, this vantage point provides a major advantage when starting new companies and sustaining a prosperous life.

Podcast: Play in new window | Download

Subscribe: Google Podcasts | Spotify | Stitcher | RSS

Episode 103: Longevity Mindset

by

Peter and Dan discuss the benefits of fostering a Longevity Mindset. Now more than ever — during a new age of exponential medicine — many will no longer have to accept the cards we’re dealt. Technologies like genome sequencing, RNA transcriptomics, Wnt pathway modifiers, novel vaccines, CRISPR, liquid biopsies, CAR-T cells, gene therapy, exosomes, and stem cells are just some of the innovations under development.

In this episode:

  • Peter reframes aging as a disease, one that many are beginning to believe can be slowed, stopped and perhaps even reversed.
  • Dan and Peter compare the process of vaccine creation today to methodologies used 10 years ago, exploring how COVID-19 has sped up all parts of the process. 
  • Peter explains why the best thing you can do for your longevity is to optimize sleep, diet and exercise, and to “not die from something stupid.”

Podcast: Play in new window | Download

Subscribe: Google Podcasts | Spotify | Stitcher | RSS

Episode 94: When the Hospital Comes To You

by

Peter and Dan discuss transformations in healthcare as a result of the pandemic and consequent stay-at-home orders. Peter envisions a future wherein people don’t go to the hospital when they get sick, but instead have a hospital at their fingertips thanks to sensors, wearables, and an abundance of personalized medical data.

In this episode:

  • Peter gives an update on COVAXX and a number of other vaccines developed for COVID-19. 
  • Dan delves into tele-health transformations within our modern-day healthcare system. 
  • Peter and Dan discuss why they believe the pandemic will speed up healthcare transformations, including: AI collaboration with physicians; drugs customized and designed for the individual; and rapid improvements in wearable hardware and commercial viability.

Podcast: Play in new window | Download

Subscribe: Google Podcasts | Spotify | Stitcher | RSS

Episode 93: Longevity Mindset: Part 3

by

Peter and Dan continue their conversation about the Abundance Platinum Longevity trip, where Peter and a select group of entrepreneurs, executives and investors spent five days learning from the top longevity and immunology experts in two of California’s top biotech hubs.

In this episode:

  • Peter talks about the importance of two technologies, vaccines and gene therapy, both with incredible medical benefits. In particular he mentions a company called Vaxxinity who is democratizing healthcare using vaccines against chronic diseases. Another company Gordion Biotechnology is using a gene therapy based discovery platform to radically improve therapeutic R&D for complex diseases of aging. 
  • Dan and Peter discuss the importance of having a longevity mindset in order to be on the content lookout for new technology breakthroughs that will allow us to live longer healthier lives. 
  • Peter gives a rapid overview of twenty companies and his biggest takeaways from his chat with the CEOs including technologies like brain computer interface, synalytic medicines for senescent cells and AI drug discovery.

Podcast: Play in new window | Download

Subscribe: Google Podcasts | Spotify | Stitcher | RSS

Episode 92: Longevity Mindset: Part 2

by

Peter and Dan continue their conversation about the recent Abundance Platinum Longevity trip, where Peter and a select group of entrepreneurs, executives and investors spent five days learning from the top longevity and immunology experts in two of California’s top biotech hubs.

In this episode:

  • Peter and Dan discuss the explosion of sensors and preventive medicine breakthroughs now emerging at the helm of today’s healthcare market. As smartphone apps and AI more seamlessly enable personalized medicine, consumers will soon be able to monitor and act upon their own health data in real-time.
  • Peter explores his biggest takeaways in the field of CRISPR and genetic engineering. Most notably, Peter showcases Mammoth Biosciences, a pioneering startup on a mission to democratize access to next-generation CRISPR tools for diagnostics and therapeutics. 
  • Peter highlights the importance of cutting out sugar from your diet, a shift critically conducive to improving longevity outcomes. He similarly emphasizes his belief that the biggest contributor to living past 80 is to not die from something stupid.

Podcast: Play in new window | Download

Subscribe: Google Podcasts | Spotify | Stitcher | RSS

Episode 91: Longevity Mindset: Part 1

by

Peter and Dan recap the recent Abundance Platinum Longevity trip, where Peter and a select group spent five days learning from the top longevity and immunity experts in two of California’s top biotech hubs.

In this episode:

  • Peter offers his biggest takeaways from the trip, including one insight from Dr. Deepak Srivastava, President of the Gladstone Institutes, who explained why heart disease remains the leading cause of morbidity and mortality in the U.S. A tremendous feat, Dr. Srivastava’s recent discovery involves using gene therapy to convert fibroblasts into heart myocytes, reversing scar tissue in the heart, and helping heart attack victims rapidly recover to live healthy lives. 
  • Dan and Peter agree that mindset is one of the most important pillars of living a long and healthy life. Peter explains why the most important goal is to “not die from something stupid,” as advances in longevity technology will have dramatic impacts on the human healthspan in the next 5-10 years. 
  • Peter talks about the power of intermittent fasting, citing a majority of featured scientists who have touted its health benefits. 

Podcast: Play in new window | Download

Subscribe: Google Podcasts | Spotify | Stitcher | RSS

Episode 88: Cracking the Vitality Code

by

Peter and Dan discuss a number of longevity and pharmaceutical companies that are working to crack the vitality code of life. Exponential technologies, from machine learning to CRISPR, are enabling scientists to probe medical data, understand aging, and reverse its processes like never before.

In this episode:

  • Peter discusses a startup he’s tracking that uses gene therapy to treat age and age-related diseases afflicting animals, extending pets’ healthy lifespans by nearly a decade, with no side effects.
  • Dan discusses a major paradigm shift in financial planning, whereby financial advisors that embrace technology are beginning to use forecasts of 120 years instead of conventional actuary tables that take by default a life expectancy of 90 years.
  • Peter and Dan emphasize the importance of a resilient mindset, purpose and long-term inspiration for individuals striving to maximize their longevity journeys.

Podcast: Play in new window | Download

Subscribe: Google Podcasts | Spotify | Stitcher | RSS

Episode 76: Adding 30 Years to Your Healthspan

by

With the rise of exponential health technologies, Peter and Dan investigate newly available business opportunities using their “first order implications” framework. When biotech advancements turn sickcare into healthcare, and science adds an additional 20-30 healthy years to our lifespans, what new markets emerge (and which ones disappear)? Peter and Dan discuss the implications to businesses, customers, and society as a whole.

In this episode:

  • Dan delves into the social implications of people having longer professional lives, predicting that mandatory retirement will be moved back by at least 10 years.
  • Peter discusses education industry transformations that will result from people having 2-3 careers. Similarly, once people begin to have far more free time, implications within the travel, tourism, and entertainment industries will unlock new challenges and business opportunities.
  • Peter forecasts our increased food demand over coming decades as people live longer. Consequently, he and Dan project a surge in the lab-grown meat market, which will lead to better-tasting, lower-waste, and far more environmentally sound food production.

Podcast: Play in new window | Download

Subscribe: Google Podcasts | Spotify | Stitcher | RSS

Episode 66: Living to 156 Years

by

Peter and Dan discuss Dan’s new book, “My Plan for Living to 156,” and their shared belief that mindset is critical to longevity. You’ll hear about one of the book’s key themes — “everyone’s got a number” — and learn why a longevity goal is extremely important in enabling a long, healthy lifespan.

 

In this episode:

  • Dan gives his biggest takeaways from the book (pick up your copy here), starting with a special tool he calls “The Lifetime Extender” and an idea to eliminate retirement.
  • Peter discusses why purpose is fundamental to longevity, and why humans are purpose-driven animals.
  • Dan and Peter describe your mindset as a skill like a muscle; just as you’d go to the gym to build muscle, you must always train your mindset. Reinventing who you are in the present when new technology comes online is critical for a happy, long life.

Podcast: Play in new window | Download

Subscribe: Google Podcasts | Spotify | Stitcher | RSS

Episode 55: The Immorality of Mortality

by

Peter and Dan discuss a recent trip to Vatican City, where the XPRIZE Vision Circle & Innovation Board members met on the annual Adventure Trip to discuss longevity and regenerative medicine, piggybacking on the United to Cure conference hosted by the Pope.

 

In this episode:

  • Peter discusses his opening remarks at the conference with fellow panelists George Church (one of the creators of gene-editing CRISPR technology), Martine Rothblatt (CEO of United Therapeutics, whose goal is to regenerate human organs), and Lou Reese and Mei Mei Hu (co-CEOs of United Neuroscience, focused on creating vaccines against Alzheimer’s and Parkinson’s disease).
  • Dan brings up three keys to longevity: 1) Friends who are progressing, not declining, 2) Enough resources and income to be independent, and 3) Having a purpose, so you look forward to a future that is much greater than the past.
  • Peter and Dan discuss how morality has evolved over time, and how some ideas that were once considered immoral are now considered miracles.

Podcast: Play in new window | Download

Subscribe: Google Podcasts | Spotify | Stitcher | RSS

Follow Peter Diamandis

Follow Dan Sullivan