Exponential Wisdom

Episode 121: Mindset Matters

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Peter and Dan discuss having a Longevity Mindset and how that affects all aspects of life. How long you live is a function of many factors, including your mindset. You can actually “Will yourself to death—or will yourself to a longer healthspan.” How long do you think you will live? 80 years old? Maybe, 90? What would have to change for you to believe that you could live to 120 years old?

In this episode:

  • Peter gives evidence of exponential medicine, and why you don’t have to accept the cards you’re dealt. Technologies like genome sequencing, RNA transcriptomics, Wnt pathway modifiers, vaccines, CRISPR, liquid biopsies, CAR-T cells, Gene Therapy, exosomes, and stem cells are just some of the technologies in development.
  • Dan explains when and how he chose the goal of living to 156 years, and how this has shaped his mindset over the years.
  • Peter and Dan agree that many things contribute to a Longevity Mindset, including what you read and watch, your community, your diet and exercise, and ultimately what you believe the future will be like.

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Episode 108: Giving Yourself Control of Your Health

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Peter and Dan discuss preventive, predictive, and personalized health care. Showcasing this phenomenon, they delve into a new health care company, Fountain Life, which uses data-driven methodologies and thorough diagnostics to identify disease early and enhance members’ physical and mental performance.

In this episode:

  • Peter explains why and how he sees healthcare evolving into a new model, one around which Fountain Life was founded to deliver emerging, best-in-class therapeutics and ground-breaking diagnostics in novel ways to enhance healthspan, performance and vitality.
  • Dan discusses a compelling platform whereby patients can identify new medical therapies and technologies and send corresponding articles or medical papers to Fountain Life’s medical advisory board, by which they can be vetted to determine their viability for the company’s offerings. 
  • Peter expresses that while testing is critical, the most important things we can prioritize are still the basics: sleep, diet and exercise. Peter and Dan give their tips for increasing quality sleep, including a temperature-controlled mattress pad, skipping TV at night, and using audiobooks to help you wind down.

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Episode 94: When the Hospital Comes To You

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Peter and Dan discuss transformations in healthcare as a result of the pandemic and consequent stay-at-home orders. Peter envisions a future wherein people don’t go to the hospital when they get sick, but instead have a hospital at their fingertips thanks to sensors, wearables, and an abundance of personalized medical data.

In this episode:

  • Peter gives an update on COVAXX and a number of other vaccines developed for COVID-19. 
  • Dan delves into tele-health transformations within our modern-day healthcare system. 
  • Peter and Dan discuss why they believe the pandemic will speed up healthcare transformations, including: AI collaboration with physicians; drugs customized and designed for the individual; and rapid improvements in wearable hardware and commercial viability.

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Episode 92: Longevity Mindset: Part 2

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Peter and Dan continue their conversation about the recent Abundance Platinum Longevity trip, where Peter and a select group of entrepreneurs, executives and investors spent five days learning from the top longevity and immunology experts in two of California’s top biotech hubs.

In this episode:

  • Peter and Dan discuss the explosion of sensors and preventive medicine breakthroughs now emerging at the helm of today’s healthcare market. As smartphone apps and AI more seamlessly enable personalized medicine, consumers will soon be able to monitor and act upon their own health data in real-time.
  • Peter explores his biggest takeaways in the field of CRISPR and genetic engineering. Most notably, Peter showcases Mammoth Biosciences, a pioneering startup on a mission to democratize access to next-generation CRISPR tools for diagnostics and therapeutics. 
  • Peter highlights the importance of cutting out sugar from your diet, a shift critically conducive to improving longevity outcomes. He similarly emphasizes his belief that the biggest contributor to living past 80 is to not die from something stupid.

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Episode 91: Longevity Mindset: Part 1

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Peter and Dan recap the recent Abundance Platinum Longevity trip, where Peter and a select group spent five days learning from the top longevity and immunity experts in two of California’s top biotech hubs.

In this episode:

  • Peter offers his biggest takeaways from the trip, including one insight from Dr. Deepak Srivastava, President of the Gladstone Institutes, who explained why heart disease remains the leading cause of morbidity and mortality in the U.S. A tremendous feat, Dr. Srivastava’s recent discovery involves using gene therapy to convert fibroblasts into heart myocytes, reversing scar tissue in the heart, and helping heart attack victims rapidly recover to live healthy lives. 
  • Dan and Peter agree that mindset is one of the most important pillars of living a long and healthy life. Peter explains why the most important goal is to “not die from something stupid,” as advances in longevity technology will have dramatic impacts on the human healthspan in the next 5-10 years. 
  • Peter talks about the power of intermittent fasting, citing a majority of featured scientists who have touted its health benefits. 

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Episode 87: How Industries Will Change

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Peter and Dan discuss the ways in which today’s pandemic will fundamentally reshape a handful of industries, from commercial aviation to education. For most of us, we will not be returning to business as usual. Rather, we will see the emergence of redefined and reorganized companies, made resilient by their need to adapt to new market conditions.

In this episode:

  • Peter and Dan evaluate a number of possible outcomes for the airplane and travel industries, as countless businesses adapt to the new paradigm of working-from-home.
  • Dan makes the case for his prediction that while technology will continue to globalize, almost every other aspect of everyday life will localize.
  • Peter and Dan delve into the future of education. As schools determine whether to pursue an additional semester of online learning, and parents play an increasingly pedagogical role, how will tomorrow’s classrooms adapt, and what impacts will we see on learning?

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Episode 45: Dangerous Ideas

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Peter and Dan delve into a number of dangerous ideas, including changing government, healthcare, and education, and discuss how these opinions are less than a decade away.

 

In this episode:

  • Peter describes a world where the blockchain enables 100% trust among strangers, which will disrupt current governments and many industries.
  • Dan discusses why he is constantly renewing relationships with people younger and younger. One key to his goal of extreme longevity is “you feel the same age as the person you’re interacting with.”
  • Peter talks about his belief that we are rapidly heading towards the end of petroleum era and moving into an all-electric economy.

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Episode 35: Science Fiction Becomes Science Reality

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Episode 35 CardPeter and Dan discuss awarding the $10 million Qualcomm Tricorder XPRIZE, which involved designing a portable wireless device that can monitor and diagnose health conditions from the palm of your hand. The prize concept originated during a lunch with Qualcomm’s Executive Chairman Paul Jacobs, a fellow Star Trek fan, when they decided the Tricorder medical device should exist.

In this episode:

  • Peter describes the power of incentive prizes with examples dating back to 1714, including the invention of canned food.
  • Considering the vast amounts of data in the healthcare field, Dan and Peter explain why AI will have a major role in democratizing healthcare, and how an AI diagnosis will ultimately be better than the best human experts in the world.
  • Peter describes the process of awarding a XPRIZE and the roadmap needed to bring technology to market.

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Episode 34: Longevity Escape Velocity

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Dan and Peter discuss their common desire to live a long and healthy life, and takeaways from Peter’s recent visit to a cutting-edge stem cell clinic in Panama.

 

 

In this episode:

  • Peter discusses his belief that if we’re able to stay alive for the next 50 years, we will have access to converging technologies that can keep us alive indefinitely — what Ray Kurzweil calls reaching “longevity escape velocity”
  • Peter explains what stem cells are and why they have the ability to rejuvenate the body.  Watch this short animation for more information: https://youtu.be/y0R4iaVOswk
  • Peter and Dan discuss the Young Blood experiments at Stanford University and what this research means for rejuvenating the human body.

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Episode 21: Inside the Future of Healthcare

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In this episode, Dan discusses his recent trip to the Human Longevity Inc. Health Nucleus and why he believes it is the best clinical experience in the world.

Many species on this planet live for hundreds of years, why should we accept a typical life expectancy of 70 or 80 years.

In This Episode:

  • Dan recaps his recent experience going through a full eight-hour day at the Human Longevity Inc. Health Nucleus.
  • Peter and Dan explain their personal longevity goals and why they believe living more than 100 healthy years is doable.
  • Peter gives examples of how algorithms with enough data are beginning to save clients by identifying early threats.

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